Clinical Trials Day is celebrated globally each May 20 to recognize the day in 1747 that James Lind, a ship’s surgeon in the British Royal Navy, started what is often considered to be the first randomized clinical trial. In this case, it was to study the effects of different treatments on scurvy, a disease caused by a deficiency of vitamin C, and a major scourge for sailors on long voyages.

Amazingly, Lind had found a cure for scurvy after carrying out a clinical trial in 12 people, of whom only two received the active treatment of citrus fruits. Many historians believe that the prevention and treatment of scurvy using citrus was the single most important factor in enhancing the physical health of the British fleet.

This story may provide hope and solace to the thousands of clinical investigators who work every day—often unsuccessfully—to explore new treatments in medicine. Although these events occurred more than 275 years ago, clinical researchers will find Lind's experiences to be familiar. Initial enthusiasm is often based on sparse data, and early findings are typically regarded with skepticism by colleagues. Once established, it can take decades for the treatment to be widely adopted. When the life of a clinical research professional feels particularly challenging, the story of James Lind can provide encouragement to keep going!